Research at
Duke-UNC Comprehensive Sickle Cell Center

Center-Based Clinical Research Projects
Nonmyeloablative Therapy for Sickle Cell Disease
     David Rizzieri, MD

Priapism in Boys and Young Men: Incidence and Prevalence
      Rupa Redding-Lallinger, MD

Center-Based Basic Research Projects
Ribozyme-Mediated Repair of Sickle b-globin RNA and DNA
        Bruce Sullenger, PhD

Activation of cAMP-mediated Sickle Cell Adhesion
        Leslie V. Parise, PhD

Inter-Center Clinical Trials:Currently Planned Trials
Arginine Supplementation in Sickle Cell Anemia: Physiological and Prophylactic Effects

Neuropsychological Dysfunction and Neuroimaging in Neurologically Intact Adult Patients with Sickle Cell Disease

Sickle Cell Scholar Program

Sickle Cell Scholar Project:
Phase I and II Studies of O-Nitrosoethanol in Sickle Cell Disease .
         Laura M. De Castro, MD

Outcome Modifying Genes in Sickle Cell Disease
Principal Investigator: Marilyn Telen, MD
Co-Investigators: Duke Center for Human Genetics
Sites:
Duke University Sickle Cell Center
UNC Sickle Cell Center
Emory Sickle Cell Center