Research at Duke

Duke University Medical Center has, since its founding, established a tradition of research to improve the health of North Carolinians, as well as individuals worldwide. Today, this tradition extends to sickle cell disease, a disease found most often in peoples of African or Arabian descent. The Comprehensive Sickle Cell Center is engaged in basic, clinical, community health, educational and psychosocial research on the myriad problems encountered by patients with sickle cell disease.

Research at
Duke-UNC Comprehensive Sickle Cell Center

Center-Based Clinical Research Projects
Nonmyeloablative Therapy for Sickle Cell Disease
     David Rizzieri, MD

Priapism in Boys and Young Men: Incidence and Prevalence
      Rupa Redding-Lallinger, MD

Center-Based Basic Research Projects
Ribozyme-Mediated Repair of Sickle b-globin RNA and DNA
        Bruce Sullenger, PhD

Activation of cAMP-mediated Sickle Cell Adhesion
        Leslie V. Parise, PhD

Inter-Center Clinical Trials:Currently Planned Trials
Arginine Supplementation in Sickle Cell Anemia: Physiological and Prophylactic Effects

Neuropsychological Dysfunction and Neuroimaging in Neurologically Intact Adult Patients with Sickle Cell Disease

Sickle Cell Scholar Program

Sickle Cell Scholar Project:
Phase I and II Studies of O-Nitrosoethanol in Sickle Cell Disease .
         Laura M. De Castro, MD

Outcome Modifying Genes in Sickle Cell Disease
Principal Investigator: Marilyn Telen, MD
Co-Investigators: Duke Center for Human Genetics
Sites:
Duke University Sickle Cell Center
UNC Sickle Cell Center
Emory Sickle Cell Center